Effect of the Y chromosome on testis weight in mice |
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| Authors: | Kunio SATOU Jun-ichi SUTO |
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| Institution: | 1)Center for Animal Disease Control and Prevention, National Institute of Animal Health, Tsukuba, Ibaraki 305–0856, Japan;2)Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305–8634, Japan |
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| Abstract: | We investigated the effect of the Y chromosome on testis weight in
(B6.Cg-Ay × Y-consomic mouse strain) F1 male
mice. We obtained the following results: (1) Mice with the Mus musculus
domesticus-type Y chromosome had significantly heavier testis than those with
the M. m. musculus-type Y chromosome. (2) Variations in
Usp9y and the number of CAG repeats in Sry were
significantly associated with testes weight. The Ay allele was
correlated with a reduced testis weight, and the extent of this reduction was
significantly associated with a CAG repeat number polymorphism in Sry.
These results suggest that Y chromosome genes not only influence testis weight but also
modify the effect of the Ay allele in mediating this
phenomenon. |
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| Keywords: | Ay allele at the agouti locus Sry CAG repeat number polymorphism testis weight Usp9y Y-consomic strains |
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