| Abstract: | A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistentrespiratory distress and recurrent generalized demodicosis. Physical examination revealedcyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsalside of the forelimbs, perineal area and skin around the eyes. A severe diffuseinterstitial lung pattern was observed on thoracic radiographs. The blood examinationrevealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG andIgA were low. Histopathological examination revealed severe diffuse interstitial pneumoniawith Pneumocystis carinii infection. Severe lymphoid depletion wasobserved in the spleen and other organs with lymphoid follicles consisted mainly ofCD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequentantibody deficiency was suspected. |
