首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia
Authors:Hideyuki KANEMOTO  Rei MORIKAWA  James Kenn CHAMBERS  Koichi KASAHARA  Yasuko HANAFUSA  Kazuyuki UCHIDA  Koichi OHNO  Hiroyuki NAKAYAMA
Abstract:A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent respiratory distress and recurrent generalized demodicosis. Physical examination revealed cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal side of the forelimbs, perineal area and skin around the eyes. A severe diffuse interstitial lung pattern was observed on thoracic radiographs. The blood examination revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection. Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent antibody deficiency was suspected.
Keywords:B-cell hypoplasia  common variable immune deficiency  Pneumocystis carinii
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号