Bone marrow stromal cells generate muscle cells and repair muscle degeneration |
| |
Authors: | Dezawa Mari Ishikawa Hiroto Itokazu Yutaka Yoshihara Tomoyuki Hoshino Mikio Takeda Shin-ichi Ide Chizuka Nabeshima Yo-ichi |
| |
Affiliation: | Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo-ku, Kyoto, 606-8501 Japan. dezawa@anat2.med.kyoto-u.ac.jp |
| |
Abstract: | Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|