Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep |
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Authors: | Picard-Hagen N Gayrard V Laroute V Grandjean C Andreoletti O Elsen J M Schelcher F Toutain P L |
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Affiliation: | Unité Mixte de Recherche, INRA-ENVT 181, Ecole Nationale Vétérinaire de Toulouse, France. |
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Abstract: | The mean (sd) concentration of plasma 20beta-dihydrocortisol in 126 scrapie-affected sheep was 5-5 (7.0) ng/ml compared with 1.1 (0.7) ng/ml in 52 healthy sheep. The mean (sd) concentration of creatinine in the urine of 93 scrapie-affected sheep was 2.43 (1.56) microg/ml compared with 0.94 (0.86) pg/ml in 49 healthy sheep and 1.10 (0-95) pg/ml in 25 sheep with other diseases. These discriminant analyses carried out on healthy and scrapie-affected sheep showed that plasma 20beta-dihydrocortisol and urinary creatinine were the best predictors of the disease, and classified correctly 98 per cent of healthy sheep and 82 per cent of scrapie-affected sheep. |
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