Thiamphenicol pharmacokinetics in beef and dairy cattle |
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| Authors: | E H ABDENNEBI R J SAWCHUK C M STOWE‡ |
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| Institution: | *Department of Pharmacology and Toxicology, Institute of Agriculture and Veterinary Medicine, Rabat, Morocco;;?Department of Pharmaceutics, Health Sciences, University of Minnesota, Minneapolis, MN 55455;?Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55 108, USA |
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| Abstract: | The pharmacokinetics of thiamphenicol were investigated in 10 calves and six lactating cows. It was found that this drug is rapidly absorbed (1 5 min) following intramuscular injection with an absorption rate constant and a bioavailability of 8.7 h-1 and 84%, respectively. The drug appears to be widely distributed into various body fluids, yielding a volume of distribution (Vd(area)) of approximately 0.9 l/kg. The micro-rate constants indicated that the antibiotic rapidly diffuses into the peripheral compartment (k12 > k21). Elimination from plasma is relatively rapid, with a biological half-life of about 1.75 h. Thiamphenicol appears shortly in milk (15 min) after its intravenous administration, and gives milk to plasma concentration ratios greater than one between 4 and 12 h. |
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