| AIV致病分子基础的研究进展 |
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| 引用本文： | 黄淑坚,廖明,辛朝安,苏广基. AIV致病分子基础的研究进展[J]. 动物医学进展, 2004, 25(3): 1-3 |
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| 作者姓名： | 黄淑坚 廖明 辛朝安 苏广基 |
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| 作者单位： | 佛山科学技术学院,广东南海,528231;华南农业大学兽医学院,广东广州,510642;华南农业大学兽医学院,广东广州,510642;广东省湛江市畜牧局,广东湛江,524038 |
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| 基金项目： | 国家自然科学基金项目 (30 10 0 136 )，国家重大基础研究项目 (G19990 1190 5 )，广东省科委攻关项目 (99B0 5 6 0 1G) |
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| 摘 要： | 在自然条件下 ,AIV感染的宿主范围有较强的特异性 ,各毒株所表现的毒力也有所不同。从 HA蛋白切割位点氨基酸序列、HA蛋白切割位点附近的糖基化位点数目、HA蛋白受体结合位点性质以及 NA茎区长度等方面 ,阐明了 AIV毒力的差异及其感染宿主特异性的分子机理 ,为更好地预防与控制 AIV奠定理论基础。下面对 AIV致病的分子基础研究进展作一综述
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| 关 键 词： | AIV 宿主 毒力 分子基础 |
| 文章编号： | 1007-5038(2004)03-0001-03 |
| 修稿时间： | 2003-09-04 |
The Progress of Study on Molecular Basis of Pathogenicity of Avian influenza virus |
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| HUANG Shu-jian. The Progress of Study on Molecular Basis of Pathogenicity of Avian influenza virus[J]. Progress In Veterinary Medicine, 2004, 25(3): 1-3 |
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| Authors: | HUANG Shu-jian |
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| Affiliation: | HUANG Shu-jian~ |
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| Abstract: | In the natural condition,there are higher specificity in the host infected by avian influenza virus, and different virulence in each of avian influenza viruses. The molecular mechanism of determinant of host specificity and difference of virulence of AIV were clarified, which involved the amino sequence of cleavage site of HA, the number of glycosylation sites besides HA cleavage site, the character of receptor binding sites of HA, the length of the stalk of NA, and so on. It provided a theorical foundation for the prevention and control of the disease caused by avian influenza virus. |
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| Keywords: | Avian influenza virus host virulence molecular basis |
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