Regression of prostatic hypertrophy by osaterone acetate in dogs |
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Authors: | Tsutsu T Hori T Shimizu M Orima H Kawakami E Fukuda S |
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Affiliation: | Department of Reproduction, Nippon Veterinary and Animal Science University, Musashino-shi, Tokyo, Japan. |
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Abstract: | The prostatic regression effect of oral administration of a new steroidal anti-androgen, osaterone acetate, was investigated in dogs with prostatic hypertrophy. To dogs with prostatic hypertrophy, 0.1-1.0 mg/kg of osaterone acetate was orally administered for one week, and the regression rate was observed. It was shown that administration of osaterone acetate at 0.2 mg/kg or higher, sharply regressed prostatic hypertrophy during the early stage. Therefore, this agent may be clinically applicable as a therapeutic agent for benign prostatic hypertrophy. |
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