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Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse |
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| Authors: | H D Christensen R I Freudenthal J T Gidley R Rosenfeld G Boegli L Testino D R Brine C G Pitt M E Wall |
| Abstract: | The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed |
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