| Oleic acid reduces steroidogenesis by changing the lipid type stored in lipid droplets of ovarian granulosa cellsOA |
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| 作者姓名： | Xiaoge Zhou Zhaoyi Mo Yankun Li Liang Huang Sihai Yu Lan Ge Yamei Hu Shengjie Shi Lutong Zhang Liguang Wang Lei Gao Gongshe Yang Guiyan Chu |
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| 作者单位： | 1. Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province;2. Laboratory of Animal Fat Deposition & Muscle Development,College of Animal Science and Technology,Northwest A&F University;3. College of Animal Science and Technology,Northwest A&F University;4. College of veterinary medicine,Northwest A&F University |
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| 基金项目： | supported by grants from the National Natural Science Foundation (No.31802047)；;the National Science and Technology Major Project of China (No. 2016ZX08006003)； |
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| 摘 要： | Background: Oleic acid is an abundant free fatty acid present in livestock that are in a negative energy-balance state, and it may have detrimental effects on female reproduction and fertility. Oleic acid induces lipid accumulation in bovine granulosa cells, which leads to a foam cell-like morphology and reduced steroidogenesis.However, why oleic acid increases lipid accumulation but decreases steroidogenesis remains unclear. This study focused on oleic acid’s effects on lipid type and steroidog...
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