3-methylindole as a model of equine obstructive lung disease |
| |
| Authors: | R G BREEZE C M BROWN M A M TURK |
| |
| Institution: | 1. Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA;2. Department of Veterinary Clinical Medicine and Surgery, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA |
| |
| Abstract: | 3-methylindole was administered orally and intravenously to horses and ponies in order to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterised by bronchiolitis. Clinical signs developed 48 to 72 h after dosing and were most severe between Days 4 and 10 post dosing. Intravenous administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. It is suggested that the respiratory condition induced by this chemical could become a method for standardisation of lung function techniques and interpretation in equine obstructive pulmonary disease. |
| |
| Keywords: | |
|
|
