| 康复新液对人工诱导的大鼠慢性溃疡性结肠炎的作用及机制初探 |
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| 引用本文： | 刘胜帅,张俊,戴莉萍,万苹,耿福能,沈咏梅,张成桂,刘衡.康复新液对人工诱导的大鼠慢性溃疡性结肠炎的作用及机制初探[J].中国兽医杂志,2019(3):100-104,I0008. |
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| 作者姓名： | 刘胜帅 张俊 戴莉萍 万苹 耿福能 沈咏梅 张成桂 刘衡 |
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| 作者单位： | 1.大理大学云南省昆虫生物医药研发重点实验室药用特种昆虫开发国家地方联合工程研究中心中国西南药用昆虫及蛛形类资源开发利用协同创新中心;2.大理白族自治州人民医院病理科;3.云南省第一人民医院消化内科;4.药用美洲大蠊四川省重点实验室 |
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| 基金项目： | 国家自然科学基金(81660605,81860742,81860765);云南省地方本科高校(部分)基础研究联合专项(2017FH001-108);云南省教育厅科学研究基金产业化培育项目(2016CYH15) |
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| 摘 要： | 为研究康复新液对人工诱导大鼠慢性溃疡性结肠炎的治疗作用并探讨其初步作用机制,采用人工诱导大鼠溃疡性结肠炎模型,灌肠给予柳氮磺胺吡啶肠溶片(Salazosulfapyridine,SASP)和康复新液高、中、低剂量药物治疗,通过大鼠DAI、CMDI、HS评分,结合血清IL-8、IL-17和结肠组织中EGF、MPO、TNF-α表达水平来评价康复新液对UC大鼠的作用。结果显示,与模型对照组比较,康复新液能降低UC大鼠的DAI、CMDI、HS评分,减少UC大鼠血清IL-8(P<0.01)、IL-17(P<0.01)和结肠组织中MPO(P<0.01)、TNF-α(P<0.01)的表达,增加组织EGF(P<0.01)的表达,明显改善UC大鼠结肠组织的病变程度。康复新液对人工诱导的大鼠溃疡性结肠炎有治疗作用,机理可能与降低大鼠IL-8、IL-17、MPO、TNF-α的表达水平,提高大鼠EGF的表达水平有关。
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| 关 键 词： | 康复新液 异体抗原 溃疡性结肠炎 柳氮磺胺吡啶肠溶片 |
Effect and Mechanism of research Kangfuxin Liquid on Artificially Induced Ulcerative Colitis in Rats |
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| LIU Sheng-shuai,ZHANG Jun,DAI Li-ping,WAN Ping,GENG Fu-neng,SHEN Yong-mei,ZHANG Cheng-gui,LIU Heng.Effect and Mechanism of research Kangfuxin Liquid on Artificially Induced Ulcerative Colitis in Rats[J].Chinese Journal of Veterinary Medicine,2019(3):100-104,I0008. |
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| Authors: | LIU Sheng-shuai ZHANG Jun DAI Li-ping WAN Ping GENG Fu-neng SHEN Yong-mei ZHANG Cheng-gui LIU Heng |
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| Institution: | (Dali University,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,National-Local Joint Engineering Research Center of Entomoceutics,Chinese southwest 2011 Collaborative Innovtion Center for Entomoceutics ,Dali 671000 ,China;Dali Bai Autonomous Prefecture People??s Hospital Department of Pathology,Dali 671000,China;The First People's Hospital of Yunnan Province Department of Gastroenterology,Kunming 650032,China;Sichuan Key Laboratory of Medicinal American Cockroach,Chengdu 61000,China) |
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| Abstract: | LIU Sheng-shuai;ZHANG Jun;DAI Li-ping;WAN Ping;GENG Fu-neng;SHEN Yong-mei;ZHANG Cheng-gui;LIU Heng(Dali University,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,National-Local Joint Engineering Research Center of Entomoceutics,Chinese southwest 2011 Collaborative Innovtion Center for Entomoceutics ,Dali 671000 ,China;Dali Bai Autonomous Prefecture People??s Hospital Department of Pathology,Dali 671000,China;The First People's Hospital of Yunnan Province Department of Gastroenterology,Kunming 650032,China;Sichuan Key Laboratory of Medicinal American Cockroach,Chengdu 61000,China) |
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| Keywords: | kangfuxin liquid Allogeneic Antigens Ulcerative Colitis Salazosulfapyridine |
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