| 米非司酮对雄性小鼠繁殖抑制作用研究 |
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| 引用本文： | 秦姣,刘全生,黄小丽,郭明防. 米非司酮对雄性小鼠繁殖抑制作用研究[J]. 广东农业科学, 2011, 38(19): 87-89,98 |
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| 作者姓名： | 秦姣 刘全生 黄小丽 郭明防 |
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| 作者单位： | 1. 广东省昆虫研究所,广东广州,510260
2. 广东省昆虫研究所,广东广州510260;中国科学院新疆生态与地理研究所,新疆乌鲁木齐830011 |
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| 基金项目： | 广州市科技计划项目(2008Z1-E101); 广东省科技计划项目(2008B020900005,2010B020311003); 广东省自然科学基金(10151026001000006) |
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| 摘 要： | 为确定米非司酮抑制雄性小鼠繁殖的有效剂量及其生理机制,以不同浓度米非司酮油溶液灌胃给药,测定了各组雄性小鼠的体重.器官、精子活力及激素等生理指标和繁殖能力.结果表明:不同剂量米非司酮处理对雄性小鼠体重、睾丸鲜重和附睾鲜重无显著影响,对精子数量和活动性影响主要在高剂量时较强,而随着剂量增加,精子的存活率显著降低且畸形率显...
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| 关 键 词： | 米非司酮 雄性小鼠 不育控制 |
Effects of mifepristone(RU-486) on reproductive success in male mice |
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| QIN Jiao,LIU Ouan-sheng,HUANG Xiao-li,GUO Ming-fang. Effects of mifepristone(RU-486) on reproductive success in male mice[J]. Guangdong Agricultural Sciences, 2011, 38(19): 87-89,98 |
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| Authors: | QIN Jiao LIU Ouan-sheng HUANG Xiao-li GUO Ming-fang |
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| Affiliation: | QIN Jiao1,LIU Quan-sheng1,HUANG Xiao-li1,2,GUO Ming-fang1(1.Guangdong Entomological Institute,Guangzhou 510260,China,2.Xinjiang Institute of Ecology and Geography,Chinese Academy of Sciences,Urumchi 830011,China) |
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| Abstract: | The purpose of study was to evaluate effects of mifepristone(RU-486) on reproduction of male mice and to explore its physiological mechanism.Body mass,organ wet mass,sperm motility,hormones and other physiological and reproductive capacity of each group mouse were determined.The results showed that body mass and wet mass of testis and epididymis of male mice were no obvious difference among five groups after RU-486 treating.The high dose of mifepristone significantly decreased sperm quantity,activity and su... |
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| Keywords: | mifepristone RU-486 male mice fertility control |
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