| 芎归胶艾汤对RU486致流产小鼠Th1/Th2型细胞因子的影响 |
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| 引用本文： | 张强,马爱团,王晓丹,杨翠华,赵德明,钟秀会. 芎归胶艾汤对RU486致流产小鼠Th1/Th2型细胞因子的影响[J]. 河北农业大学学报, 2009, 32(1) |
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| 作者姓名： | 张强 马爱团 王晓丹 杨翠华 赵德明 钟秀会 |
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| 作者单位： | 中国农业大学,动物医学院,北京,100094;河北省畜牧兽医局,河北,石家庄,050031;河北农业大学,中兽医学院,河北,定州,073000;中国农业大学,动物医学院,北京,100094 |
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| 基金项目： | 国家自然科学基金，河北省畜牧局资助项目 |
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| 摘 要： | 为了研究芎归胶艾汤的促孕保胎作用及其对母胎界面Th1/Th2型细胞因子的影响,取怀孕小鼠分成4组,分别为对照组、RU486组、RU486+孕酮组、RU486+芎归胶艾汤组。除对照组外,其它3组于孕4 d(GD4)7:00皮下注射RU486 0.5 mL,同时孕酮组注射0.1 mL孕酮,中药组灌服芎归胶艾汤0.8 mL,各组分别在GD4下午19:00,GD5上午7:00,GD5下午19:00取材。统计胚泡数,酶联免疫吸附法(ELISA)测定子宫匀浆中IFN-γ、IL-2、IL-4和IL-10的含量。结果表明:RU486显著降低胚泡数,Th1型细胞因子IFN-γ和IL-2的水平显著升高,Th2型细胞因子IL-4和IL-10的含量显著下降。补充孕酮或芎归胶艾汤显著逆转了RU486引起的流产,同时降低了Th1型细胞因子水平,提高了Th2型细胞因子水平,表明芎归胶艾汤能够作用在母胎界面,调节着床和妊娠期细胞因子平衡,利于胚胎着床和妊娠维持。
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| 关 键 词： | RU486 孕酮 芎归胶艾汤 Th1/Th2 流产 |
Effect of Xiong-gui-jiao-ai tang on Th1/Th2 cytokines of abortive mice induced by RU486 |
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| ZHANG Qiang,MA Ai-tuan,WANG Xiao-dan,YANG Cui-hua,ZHAO De-ming,ZHONG Xiu-hui. Effect of Xiong-gui-jiao-ai tang on Th1/Th2 cytokines of abortive mice induced by RU486[J]. Journal of Agricultural University of Hebei, 2009, 32(1) |
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| Authors: | ZHANG Qiang MA Ai-tuan WANG Xiao-dan YANG Cui-hua ZHAO De-ming ZHONG Xiu-hui |
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| Affiliation: | 1.College of Veterinary Medicine;China Agricultural University;Beijing 100094;China;2.Office of Animal Science and Veterinary Medicine;Hebei Province;Shijiazhuang 050031;3.College of Traditional Chinese Veterinary Medicine;Agricultural University of Hebei;Dingzhou 073000;China |
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| Abstract: | To investigate the effect of Xiong-gui-jiaoai tang(XGJAT) on abortion model and its impact on Th1/Th2 cytokines at the maternal-fetal interface,the pregnant mice were divided into 4 groups: control group,RU486 group,RU486+progesterone(P) group and RU486+XGJAT group.All mice except the control were injected with 0.5 mL RU486 subcutaneously on day 4 of pregnancy to establish abortion model.At the same time,the mice in RU486+P group were injected with 0.1 mL progesterone and those of RU486+XGJAT group gavaged ... |
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| Keywords: | RU486 Th1/Th2 |
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