Corneal squamous cell carcinoma in a dog: a case report |
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Authors: | Montiani-Ferreira Fabiano Kiupel Matti Muzolon Patricia Truppel Jesse |
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Institution: | Universidade Federal do Paraná(UFPR), Rua dos Funcionários, 1540, 80035-050, Curitiba, Paraná, Brazil;;Michigan State University, Department of Small Animal Clinical Sciences, D-208, Veterinary Medical Center, East Lansing, MI 48824-1314, USA;;Michigan State University, Department of Pathobiology and Diagnostic Investigations, Diagnostic Center for Population and Animal Health, 4125 Beaumont Road, 152A, Lansing, MI 48910, USA;;Department of Basic Pathology, Universidade Federal do Paraná(UFPR), Setor de Ciências Biológicas, Centro Politécnico, Jardim da Américas, Caixa Postal: 190-31, 81531-980, Curitiba, Paraná, Brazil |
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Abstract: | Purpose: To report a case of primary corneal squamous cell carcinoma (SCC) in an English Bulldog. In addition, immunohistochemistry of the corneal tissue mass was performed using a panel of antibodies. A prominent feature of the present case was the clinical history of chronic keratitis due to eyelid abnormalities. Results: No papillomavirus antigen was detected in section of normal or neoplastic corneal tissue. The corneal epithelial cells were positive for pancytokeratins AE1/AE3 and MNF116, and E-cadherin. The neoplastic cells in close proximity to the normal epithelial lining were positive for both pancytokeratins and E-cadherin with gradual loss of staining toward the center of the neoplastic mass. Rare neoplastic cells demonstrated positive staining for caspase 3 and a large number was strongly positive for GADD45 and p53. Conclusion and discussion: The observed loss of the various cytokeratins, the strong p53 expression, and low numbers of caspase 3 positive cells were suggestive that a p53 mutation may have caused this primary corneal SCC. Over-expression of the tumor-suppressor gene p53 is likely to be a consequence of ultraviolet radiation exposure. Two factors, however, may have played a role in the formation of this primary corneal SCC: chronic irritation of the corneal surface (microtrauma) and exposure to UV radiation. |
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Keywords: | canine cornea immunohistochemistry squamous cell carcinoma |
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