Pharmacokinetics and dosage regimen of cefotaxime in cross-bred calves following single intramuscular administration |
| |
Authors: | S K Sharma A K Srivastava |
| |
Institution: | (1) Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004 Ludhiana, India |
| |
Abstract: | The pharmacokinetics, penetration into erythrocytes and plasma protein binding of cefotaxime were investigated in cross-bred calves. Following a single intramuscular dose of cefotaxime (10 mg/kg), the absorption half-life and elimination half-life were 0.13±0.03 h and 2.97±0.72 h, respectively. The apparent volume of distribution and total body clearance were 3.28±0.72 L/kg and 0.78±0.08 L/kg per h, respectively. The extent of penetration into erythrocytes was 24–40% of the total blood concentration. Cefotaxime was bound to plasma proteins of calves to the extent of 25.5–33.6%. A satisfactory intramuscular dosage regimen for cefotaxime in calves would be 11 mg/kg followed by 10 mg/kg at 7 h intervals.Abbreviations ATCC
American type cell culture
- MIC
minimum inhibitory concentration
- PCV
packed cell volume |
| |
Keywords: | calves cefotaxime cephalosporin dose intramuscular pharmacokinetics |
本文献已被 SpringerLink 等数据库收录! |