| 臭氧减菌化处理罗非鱼片的急性毒性与遗传毒性 |
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| 引用本文： | 赵永强,杨贤庆,李来好,钟志勇,郝淑贤,武昕,魏涯,岑剑伟.臭氧减菌化处理罗非鱼片的急性毒性与遗传毒性[J].水产学报,2014,38(8):1182-1189. |
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| 作者姓名： | 赵永强 杨贤庆 李来好 钟志勇 郝淑贤 武昕 魏涯 岑剑伟 |
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| 作者单位： | 中国水产科学研究院南海水产研究所,中国水产科学研究院南海水产研究所,中国水产科学研究院南海水产研究所,广东省医学实验动物中心,中国水产科学研究院南海水产研究所,广东省医学实验动物中心,中国水产科学研究院南海水产研究所,中国水产科学研究院南海水产研究所 |
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| 基金项目： | 国家自然科学基金；国家现代农业产业技术体系建设专项资金；国家“十二五”科技支撑计划项目；中央级公益性科研院所基本科研业务费专项资金项目。 |
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| 摘 要： | 为评价经臭氧处理后罗非鱼片产品的安全性,本研究分别采用SD大鼠急性经口毒性实验与KM小鼠遗传毒性实验来研究经臭氧处理后罗非鱼片的急性毒性与遗传毒性。结果显示:臭氧处理后的罗非鱼片对SD大鼠经口最大耐受剂量MTD15 g/kg;无论有无S9代谢活化系统,罗非鱼片5个剂量组TA97、TA98、TA100、TA102菌株的回变菌落数最大值为(156±10)个/皿,均未超过阳性对照组TA97、TA98、TA100、TA102菌株回变菌落数最小值(1 773±83)个/皿]的2倍,重复实验结果一致;罗非鱼片高、中、低剂量小鼠的骨髓微核率分别为(0.40‰±0.88‰)(♀)/(0.40‰±0.83‰)(♂)、(0.60‰±0.89‰)(♀)/(0.80‰±1.29‰)(♂)与(0.80‰±1.09‰)(♀)/(0.60‰±0.89‰)(♂),与溶剂对照组微核率(1.20‰±1.29‰)(♀)/(0.40‰±0.89‰)(♂)相比无显著性差异(P0.05);罗非鱼片高、中、低剂量组小鼠睾丸染色体总畸变率分别为0.2%、0.2%和0.1%,与溶剂对照组总畸变率0.2%相比无显著性差异(P0.05)。研究表明:Ames实验、KM小鼠骨髓微核实验及睾丸染色体畸变实验结果均为阴性,经4.5 g/mL臭氧水处理30 min后的罗非鱼片毒性分级为无毒且无遗传毒性。
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| 关 键 词： | 臭氧减菌化 罗非鱼片 急性毒性 遗传毒性 |
| 收稿时间： | 2014/1/17 0:00:00 |
| 修稿时间： | 2014/5/18 0:00:00 |
Acute toxicity test and genetic toxicity study of Nile tilapia fillets sterilized by ozone treatment |
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| ZHAO Yongqiang,YANG Xianqing,LI Laihao,ZHONG Zhiyong,HAO Shuxian,WU Xin,WEI Ya and CEN Jianwei.Acute toxicity test and genetic toxicity study of Nile tilapia fillets sterilized by ozone treatment[J].Journal of Fisheries of China,2014,38(8):1182-1189. |
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| Authors: | ZHAO Yongqiang YANG Xianqing LI Laihao ZHONG Zhiyong HAO Shuxian WU Xin WEI Ya and CEN Jianwei |
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| Institution: | Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science,Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science,Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science,,Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science,,Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science,Key Lab. of Aquatic Product Processing,Ministry of Agriculture,National R D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Science |
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| Abstract: | |
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| Keywords: | Tilapia fillets sterilized by ozone treatment acute toxicity genetic toxicity |
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