鸟氨酸脱羧酶结构、功能及表达调控研究进展

多胺对细胞生长、存活以及增殖具有重要的调控作用,体内多胺水平变化与疾病和衰老的关系密切。鸟氨酸脱羧酶(Ornithine decarboxylase,ODC)是多胺生物合成途径中的第一个限速酶,能催化细胞内鸟氨酸脱羧转化成腐胺。因此,ODC可通过对细胞内多胺水平的调节来参与调控细胞增殖过程。近年来,对ODC功能的研究取得了一定的进展,特别是在ODC调控多胺水平、细胞增殖、癌症以及ODC表达调控等方面研究较多。文章对ODC结构、功能及其表达调控的研究进行了评述,并对今后ODC的深入研究进行了展望。

Research progress on characterization,function and expression regulation of ornithine decarboxylase

Polyamines play important roles in cell growth,survival and proliferation.Changes in polyamine levels have been associated with diseases and aging.Ornithine decarboxylase (ODC),the first rate limiting enzyme in the polyamine biosynthesis,catalyzes the decarboxylation of ornithine to yield putrescine.Therefore,ODC can involve in cell proliferation by regulating polyamines amount in vivo.In recent years,significant progresses have been made on ODC function,particularly in polyamine levels regulated by ODC,cell proliferation,cancer and regulation of ODC expression.In this review, the molecular characterization,function and expression regulation of ODC were described and the future research directions were prospected.