转基因动物在免疫学研究中的应用

转基因动物技术在分子免疫、免疫耐受、自身免疫、移植免疫、抗感染免疫和免疫防治等研究中的应用日益广泛。表达功能性重排的 T细胞抗原受体 (TCR)的转基因动物的应用加深了人们对 TCR基因重排、T细胞在胸腺中的发育过程、αβT细胞和γδT细胞分化途径及 T细胞免疫耐受形成机制的认识 ;免疫分子及其受体转基因动物成为研究其功能的直接手段 ;病毒及病毒受体转基因动物为研究病毒致病机制、抗病毒治疗及疫苗评价提供了新的模型 ;自身免疫病和用于移植免疫研究的转基因动物模型成为探讨疾病发病机制及治疗手段的有力工具。目前利用转基因动物已生产出多种抗体、干扰素、IL-2、TNFα、G-CSF、L F等诊断和治疗性生物活性蛋白

Applications of Transgenic Animals in the Research of Immunology

There are more and more applications in integrating transgenic technology into immunology, especially in molecular immunology, immunological tolerance, autoimmunity, transplantation immunity, anti-infectious immunity, immunoprophylaxis and immunotherapy.TCR transgenic animals have boosted the cognition about the growth, differentiation and tolerance of T lymphocyte. Immune molecules and their receptor transgenic animals have been direct means to study their functions.Viruse transgenic animals are new models to study the pathogenesis, treatment and vaccine of viruses.More autoimmune and transplantation transgenic models have been used in the study of their pathogenesis and treatment.Now there are many functional proteins produced by transgenic animals such as antibodies, IFN,IL-2,TNF,LF and so on.