Chemical constituents from Gmelina arborea bark and their antioxidant activity |
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Authors: | Syamsul Falah Takeshi Katayama Toshisada Suzuki |
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Institution: | (1) Faculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, Japan |
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Abstract: | Gmelina arborea Roxb. is a fast-growing species and is known to have been used in traditional Indian medicine. Chemical constituents from
the bark have not been reported, although some chemical constituents from part of this plant (heartwood, leaf, and root) are
known. In this study, the bark meal was successively extracted with acetone and methanol. Fractionation of the acetone extract
with n-hexane, diethyl ether, and ethyl acetate and subsequent chromatographic separation of the fractions led to the isolation
of four compounds. The diethyl ether-soluble fraction yielded tyrosol 2-(4-hydroxyphenyl)ethanol] (1); (+)-balanophonin (2), an 8-5′ neolignan, with opposite optical rotation to known (−)-balanophonin; and gmelinol (3), a known lignan. The ethyl acetate-soluble fraction afforded a new phenylethanoid glycoside to the best of our knowledge,
which was identified as (−)-p-hydroxyphenylethyl5′″-O-(3,4-dimethoxycinnamoyl)-β-d-apiofuranosyl(1′" → 6′)]-β-d-glucopyranoside (4). From the methanol extract, two known compounds, 2,6-dimethoxy-p-benzoquinone (5) and 3,4,5-trimethoxyphenol (6), were isolated and identified. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay of the identifi ed
compounds indicated that 3,4,5-trimethoxyphenol (6) exhibited moderate activity.
Part of this report was presented at the 57th and 58th Annual Meetings of the Japan Wood Research Society, Hiroshima and Tsukuba,
August 2007 and March 2008, respectively |
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Keywords: | Gmelina arborea Roxb Bark extractives Phenylethanoid glycoside Antioxidant activity |
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