| 冰片和薄荷醇对伊维菌素体外透皮效果的研究 |
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| 引用本文： | 王佳,孙静静,陈俊红,戴鼎震.冰片和薄荷醇对伊维菌素体外透皮效果的研究[J].安徽农业科学,2013(27):11061-11063. |
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| 作者姓名： | 王佳 孙静静 陈俊红 戴鼎震 |
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| 作者单位： | 金陵科技学院,江苏南京,211169;金陵科技学院,江苏南京,211169;金陵科技学院,江苏南京,211169;金陵科技学院,江苏南京,211169 |
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| 基金项目： | 江苏省产学研前瞻性项目(BY2011114);南京市科技发展项目(201201026);南京市科技计划项目(2012ZD006) |
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| 摘 要： | 目的]筛选出效果最好的促透剂比例。方法]试验采用两室扩散池试验装置，选取鸽子皮肤，比较1％-5％的冰片和薄荷醇对伊维菌素的透皮吸收的量效关系，计算出12h内累计的透过量和渗透系数。结果]冰片和薄荷醇对伊维菌素的最佳促透浓度均为4％。其中．4％薄荷醇12h的累积透过量高于4％的冰片，同时4％薄荷醇单位时间内稳定透过量高于4％冰片。结论]体外透皮模拟试验表明薄荷醇的最佳促透比例为4％。
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| 关 键 词： | 冰片 薄荷醇 促透 |
The Influence of lvermectin by Transdermal after Using Borneol and Menthol |
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| Institution: | WANG Jia et al (Jingling Institute of Technology, Nanjing, Jiangsu 211169 ) |
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| Abstract: | Objective] To screen the best concentration for transdermal enhancers. Method] Pigeon＇ s skin was cut and a 2 - chamber dif- fusion cell was adopted. Then work out the accumulated permeation and percolation coefficient within 12h through comparihg the absorbed dose of ivermectin for borneo of 1% -5% with menthol. Result] The results showed that the best concentration for borneo and menthol are 4%. The accumulated permeation of menthol 0f4% is higher than that of borneo in 12h. The same conclusion could also draw from percolation co- efficient. Conclusion] So, it can be concluded from the test that the best concentration for menthol is 4%. |
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| Keywords: | Borneol Menthol Penetration |
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