Biochemical Markers of Bone Modeling and Remodeling in Juvenile Racehorses at Varying Mineral Intakes |
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| Institution: | 1. Bio-oriented Technology Research Advancement Institution, National Agricultural and Food Research Organization, 1-40-2 Nisshin, Kita-ku, Saitama 331-8537, Japan;2. BRAIN, NARO, Japan;1. Centro para el Desarrollo de la Agricultura Sostenible, Instituto Valenciano de Investigaciones Agrarias (CDAS-IVIA), Apartado oficial, 46113, Moncada, Spain;2. Estación Experimental Agraria de Carcaixent, Instituto Valenciano de Investigaciones Agrarias, Partida del Barranquet s/n., 46740, Carcaixent, Spain;1. Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China;2. Key Lab for Food Safety and Risk Assessment, Ministry of Public Health & China Center for Food Safety Risk Assessment, 7 Panjiayuan Nan Li, Chao Yang District, Beijing 100021, China;3. Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA;4. Key Lab of Chemical Safety and Health, Chinese Center for Disease Control and Prevention & National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 27 Nan Wei Road, West City District, Beijing 100050, China |
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| Abstract: | In this study, blood-borne biochemical markers were used to track comparative rates of bone turnover in horses fed differing amounts of Ca, P and Mg. Bone turnover was tracked by serum osteocalcin; bone resorption by the carboxyterminal telopeptide of type I collagen (ICTP); and bone formation by the carboxyterminal propeptide of type I procollagen (PICP). Twenty-one longyearling Quarter Horses were blocked by gender and age, randomly assigned to one of four diets and subjected to 128 d of race training. The study was conducted in 32-d periods, each consisting of 28 d of race training followed by a 4-d fecal and urine collection, or a 4-d rest period. Blood samples were taken weekly during the training period. Serum and plasma samples were analyzed for biochemical markers of bone activity using RIA procedures. Onset of training resulted in elevated blood concentrations of ICTP, PICP and osteocalcin. Concentrations of ICTP and PICP were greater during the first 64 d of training, indicating increased bone activity during the first half of the training period. Horses with the greatest intake of minerals exhibited greater concentrations of PICP (bone formation marker) and lesser concentrations of ICTP (bone breakdown marker). Further, ICTP, PICP and osteocalcin concentrations decreased dramatically following 4-d of confinement and relative inactivity. Therefore it appears that feeding minerals at levels greater than current NRC recommendations provided a protective effect on the developing skeleton of the young racehorse. Additionally, the biochemical markers used in this study were sensitive enough to track daily changes in bone activity resulting from daily changes in stress to the skeleton. |
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