IgE and IgG antibodies to flea antigen in differing dog populations |
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Authors: | R E Halliwell S J Longino |
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Institution: | Blanche Saunders Dermatology Laboratory, Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, U.S.A. |
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Abstract: | A radioimmunoassay was developed for the detection of IgG and IgE canine antibodies against partially purified flea antigen. Low background levels were found in flea naive dogs, but high levels of both IgE and IgG antibodies were found in many sera from dogs with clinical flea hypersensitivity. In sera from non-allergic dogs exposed chronically to fleas, IgE levels differed little from background, and levels of IgG anti-flea antibodies were much lower than those from the flea allergic group. The results suggest that chronic flea exposure may result in partial or complete tolerance rather than hyposensitization in the commonly accepted sense. |
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