Sulfated glycofuranans as inhibitors of melanoma lung metastasis |
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| Authors: | Hiroshi Kamitakahara Fusako Nishigaki Yuji Mikawa Michiko Hori Shigetomo Tsujihata Takashi Fujii and Fumiaki Nakatsubo |
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| Institution: | (1) Division of Forest and Biomaterials Science, Graduate School of Agriculture, Kyoto University, Sakyo-ku, 606-8502 Kyoto, Japan;(2) Medicinal Biological Research Laboratories, Fujisawa Pharmaceutical Co., 532-8514 Osaka, Japan;(3) Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., 300-2698 Ibaraki, Japan |
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| Abstract: | Chemically synthesized (1  5)- -d-glucofuranan, (1 5)--d-galactofuranan, (1 5)--d-xylofuranan, (1 5)- -L-arabinofuranan, natural xylan, and curdlan were sulfated to investigate their inhibitory activities on B16-BL6 lung metastasis and anticoagulant activities. (1 5)--d-Glucofuranan sulfate, (1 5)--d-galactofuranan sulfate, xylan sulfate, and curdlan sulfate had binding abilities with B16-BL6 melanoma lysate. The inhibitory activities of sulfated polysaccharides on B16-BL6 lung metastasis selected by heparin binding assay were in the order (1 5)--d-galactofuranan sulfate > (1 5)---d-glucofuranan sulfate > xylan sulfate  curdlan sulfate. Furthermore, (1 5)--d-galactofuranan sulfate, (1 5)--d-glucofuranan sulfate, and xylan sulfate had not only high inhibitory activity on B16-BL6 lung metastasis but also low anticoagulant activity. The correlation between chemical structure and biological activity is discussed.Part of this paper was presented at the 10th International Synposium on Wood and Pulping Chemistry, Yokohama, Japan, June 1999 |
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| Keywords: | Glycofuranan Sulfated polysaccharide Melanoma lung metastasis Anticoagulant activity Heparin |
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