Viridepyronone, a new antifungal 6-substituted 2H-pyran-2-one produced by Trichoderma viride |
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Authors: | Evidente Antonio Cabras Annalisa Maddau Lucia Serra Salvatorica Andolfi Anna Motta Andrea |
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Affiliation: | Dipartimento di Scienze del Suolo, della Pianta e dell'Ambiente, Università di Napoli Federico II, 80055 Portici, Italy. evidente@unina.it |
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Abstract: | A new antifungal 6-substituted 2H-pyran-2-one, named viridepyronone, has been isolated from a cultural filtrate of a strain of Trichoderma viride showing antagonistic activity in vitro toward Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridepyronone was characterized as 6-(4-oxopentyl)-2H-pyran-2-one 2 with spectroscopic methods. Bioassays showed that viridepyronone had a good antifungal activity against S. rolfsii, and its minimum inhibitory concentration (over 90% inhibition) was found to be 196 microg/mL. This is the first report of viridepyronone produced by any species of fungi. |
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