| N-取代苯基-2-(苯并异噻唑啉-3-酮-2-基)甲酰胺的合成及抑菌活性 |
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| 引用本文： | 王向辉,尹学琼,冯文,杨建新,林强. N-取代苯基-2-(苯并异噻唑啉-3-酮-2-基)甲酰胺的合成及抑菌活性[J]. 农药学学报, 2012, 14(2): 225-228 |
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| 作者姓名： | 王向辉 尹学琼 冯文 杨建新 林强 |
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| 作者单位： | 1.昆明理工大学 环境科学与工程学院,昆明 650093 |
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| 基金项目： | 国家自然科学基金项目(20962007). |
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| 摘 要： | 通过取代苯异氰酸酯与1,2-苯并异噻唑啉-2(3H)-酮(BIT)反应,制备了13个2-(苯并异噻唑啉-3-酮-2-基)甲酰胺类化合物,其中9个未见文献报道。所有化合物的结构均经IR、1H NMR和元素分析确认。初步的抑菌活性测定结果表明,部分目标化合物对供试病原菌具有很好的抑菌活性,尤其对于枯草芽孢杆菌Bacillus subtilis和芒果蒂腐病菌Botryodiplodia theobromae,大部分化合物在50 mg/L下的抑制率在80%~100%之间。
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| 关 键 词： | 1 2-苯并异噻唑啉-2(3H)-酮 合成 抑菌活性 |
| 收稿时间： | 2011-12-18 |
| 修稿时间： | 2012-01-12 |
Synthesis and antibacterial and fungicidal activity of 3-oxo-N-arylbenzo[d]isothiazole-2(3H)-carboxamides |
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| WANG Xianghui,YIN Xueqiong,FENG Wen,YANG Jianxin and LIN Qiang. Synthesis and antibacterial and fungicidal activity of 3-oxo-N-arylbenzo[d]isothiazole-2(3H)-carboxamides[J]. Chinese Journal of Pesticide Science, 2012, 14(2): 225-228 |
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| Authors: | WANG Xianghui YIN Xueqiong FENG Wen YANG Jianxin LIN Qiang |
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| Affiliation: | 1.Institute of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China2.College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China3.College of Material and Chemical Engineering, Hainan University, Haikou 570228, China4.Hainan Chuntch Pharmaceutical Co., Ltd, Haikou 570000,China |
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| Abstract: | Thirteen 3-oxo-N-arylbenzo[d]isothiazole-2(3H)-carboxamide derivatives were synthesized via reaction of 1,2-benzisothiazol-2(3H)-one with substituted phenyl isocyanate.Among them nine compounds were not reported.Their structures were confirmed by elemental analyses,IR and 1H NMR.Priliminary bioassays showed that some of the compounds exhibit 80%-100% inhibition rate against Bacillus subtilis and Botryodiplodia theobromae at the concentration of 50 mg/L. |
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| Keywords: | 1,2-benzisothiazol-2(3H)-one synthesis fungicidal activity |
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