Isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of Indonesian marine habitats |
| |
Authors: | Tarman Kustiariyah Lindequist Ulrike Wende Kristian Porzel Andrea Arnold Norbert Wessjohann Ludger A |
| |
Institution: | Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. |
| |
Abstract: | In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product. |
| |
Keywords: | Indonesian marine fungi algicolous fungi antifungal bioactive compounds |
本文献已被 PubMed 等数据库收录! |