围产期奶牛氧化应激、抗氧化防御系统及其与机体炎症反应的关系

氧化应激诱导机体自由基的产生是有氧代谢的一个组成部分。活性氧(reactiveoxygenspecies,ROS)是机体正常代谢过程和某些白细胞群体在疾病防御过程中产生的。越来越多的研究表明,机体组织和细胞产生的氧化损伤会直接或间接诱导许多疾病的发生,进而影响动物健康和福利。高产奶牛的生产性能在一定程度上可通过补充抗氧化剂来优化。概述了氧化应激的研究进展,综述了围产期奶牛氧化应激、抗氧化防御系统及其与炎症反应的关系,以期为进一步揭示抗氧化剂预防免疫功能障碍和宿主组织氧化损伤的分子机理,避免围产期奶牛发生由氧化应激诱导的代谢病和临床型疾病提供新思路。

Research Progress on Oxidative Stress and Antioxidant Defense System and Their Relationship with Inflammatory Response in Perinatal Dairy Cows

The production of free radicals induced by oxidative stress is an integral part of aerobic metabolism. Reactive oxygen species（ROS） are produced in normal metabolic processes and by certain white blood cell populations during disease defense. More and more studies have shown that oxidative damage of tissues and cells can directly or indirectly induce the occurrence of many diseases, and then affects the health and welfare of animals. The production performance of high-yielding dairy cows can be optimized by supplementing antioxidants to a certain extent. This paper reviewed the research progress on oxidative stress and antioxidant defense system, and expounded their relationship with inflammatory response in perinatal dairy cows, in hoping to further reveal the molecular mechanism of antioxidants in preventing immune dysfunction and oxidative damage of host tissues, and to avoid the occurrence of metabolic diseases and clinical diseases induced by oxidative stress in perinatal dairy cows.