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Variations in the immune response to herpesvirus saimiri in squirrel and rhesus monkeys |
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| Authors: | Giancarlo Pizza Paul H Levine Dharam V Ablashi Gary Armstrong Zakir Bengali Grace B Cannon |
| Affiliation: | National Cancer Institute, Bethesda, MD 20205, U.S.A. Litton Bionetics, Inc., Kensington, MD 20795, U.S.A. |
| Abstract: | Humoral and cell-mediated immunity (CMI) to herpesvirus saimiri (HVS), an oncogenic lymphotropic herpesvirus, was studied in squirrel and rhesus monkeys. Natural antibody to HVS was found in five of six squirrel monkeys but there was no evidence of specific CMI directed against HVS. Rhesus monkeys did not show natural antibody or CMI against HVS antigens. Immunization with HVS, however, produced both antibody and specific CMI in the rhesus monkeys, but no CMI developed in the squirrel monkeys. These findings are important in the development of animal models for the treatment of tumors associated with lymphotropic herpesviruses. |
| Keywords: | Herpesvirus saimiri immunity squirrel monkeys rhesus monkeysAuthor Keywords: Herpès virus saimiri immunité singes écureuil singes rhesus |
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