Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies |
| |
| Authors: | Anton N Yurchenko Elena V Girich Ekaterina A Yurchenko |
| |
| Institution: | 1.Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russia Academy of Sciences, 690022 Vladivostok, Russia; (A.N.Y.); (E.V.G.);2.Laboratory of Bioassays and Mechanisms of Action of Biologically Active Substances, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russia Academy of Sciences, 690022 Vladivostok, Russia |
| |
| Abstract: | Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020. |
| |
| Keywords: | marine sediments fungi secondary metabolites antiviral activity antimicrobial activity cytotoxic activity cytoprotective activity |
|
|
