羊传染性脓疱皮炎病毒研究进展

羊传染性脓疱皮炎病毒（ORFV）是痘病毒科副痘病毒属的代表种，具有高度的嗜上皮性，主要引起人和动物的接触传染性皮炎。本病传染性强、发病率高，呈世界性流行，给养羊业带来巨大的经济损失，并对人类健康构成威胁，具有一定的公共卫生学意义。ORFV不同毒株抗原性的差异及被感染动物表现出临床症状的不同，给该病的诊断和防治造成了困难。作者对近年来国内外学者在病毒基因组的组成、病毒编码的主要功能蛋白、免疫特性、致病机理及诊断与防治等方面取得的进展作一综述，以期为ORFV的预防与控制提供科学依据。

The Research Progress of Orf Virus

Orf virus(ORFV) is the prototype species of the parapoxvirus genus of the poxviridae which has intensive eruptive skin.It mainly causes a highly contagious ecthyma in humen and animals.The disease which has high infectivity and morbidity is found throughout the world.The disease can cause huge economic loss for ovine husbandry and threaten the health of humen,so it has important significance of public health.The difference of antigen of distinct strains and clinical symptom of infected animals causes difficulties for the diagnosis and the prevention and cure of the disease.Recent years,researchers all over the world have been deeply researched ORFV and have gotten plenty of important progress especially on ORFV genome constitutions,main functional proteins of ORFV,pathogenic mechanism and diagnosis and prevention.The results provide a basic foundation on prevention and control of the disease.