Failure to Induce Contact Hypersensitivity in the Opossum,Ittrichosurus Vulpecula |
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| Authors: | K. M. Moriarty M. J. Thomas |
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| Affiliation: | Department of Veterinary Pathology and Public Health , Massey University , Palmerston North |
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| Abstract: | Abstract Sir:- Contact hyypersensitivity (CHS; syn: contact allergy, contact dermatitis, contact eczema) is induced when chemicals (haptens) capable of binding covalently to autologous proteins are applied to the skin.(1) Claman,, H. N.,, Miller,, S. D.,, Conlon,, P. J. and Moorehead,, J. W. 1980. Advances in Immunology, Edited by: Dixon and, F. J. and Kunkel, H. G. 121–157. New York: Academic Press. [Google Scholar]The hapten-protein complexes formed in this way are immunogenic and elicit the immune response underlying CHS. CHS is a form of delayed hypersensitivity. Exposure of a primed animal to the sensitising hapten results in erythema and induration at the site of skin contact, the response being maxima1 after 24 hours. |
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