Some features of the antibody response of sheep

Six nine-month-old red deer were injected intramuscularly with a long-acting injectable solution of oxytetracycline (“Terramycin-LA”, Pfizer Ltd) at a dose rate of 20 mg/kg. Four similar control deer were injected with saline. There was no significant pain response to injection, and only minor palpable swellings at the injection site were observed in three oxytetracycline-treated and one control animal. No statistically significant changes in white blood cell numbers, blood fibrinogen, creatine Phosphokinase or glutamic oxaloacetic transaminase concentrations occurred as a result of Oxytetracycline administration up to seven days after injection. Mean plasma Oxytetracycline concentration reached a peak (4.68 mg/1) two hours after injection and declined to levels below assay sensitivity (0.3 mg/1) in five deer 72 hours after injection, and in all deer by 96 hours after injection. No gross lesions at the injection site were observed at slaughter 30 days after injection. There were traces of Oxytetracycline at the injection site muscle of two deer after 30 days, but residues were not detected in injection site muscle from the other four deer, or in any of the liver, kidney or other muscle specimens.