Field trials with trimethoprim and sulphadoxine |
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| Authors: | T.F. Cook M.R.C.V.S. G.V. Wallace B.V.SC. |
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| Affiliation: | 1. Cooper, McDougall &2. Robertson (N.Z.) Ltd. , 731-733 Great South Road, Otahuhu |
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| Abstract: | Extract Sir, — Trimethoprim (2,4-diamino-5-(3,4,5,trimethoxy-benzyl) pyrimidine) is an inhibitor of the enzyme dihydrofolate reductase and blocks its action in bacterial cell metabolism. Sulphonamides act similarly on a different enzyme and, when the two are used in combination, clinical results are much enhanced and a synergistic effect has been shown in vitro. |
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