Pathology of 2-alkyl and 2-hydroxy naphthoquinone toxicity in rats |
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| Authors: | BL Smith R Munday |
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| Institution: | Toxicology and Food Safety Research Group, AgResearch , Ruakura Research Centre , Hamilton, New Zealand |
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| Abstract: | Extract The oral administration of 2-methyl-1, 4-naphthoquinone (menadione) to rats caused oxidative destruction of the erythrocyte. Heinz body formation occurred in erythrocytes, lowered PCVs and haemoglobin Occurred in blood, with splenic and hepatic erythroclasis, and iron conservation in the spleen, liver and kidney. These effects diminished when increasingly large alkyl substitutions of the methyl group of thi naphthoquinone were made. No effect was caused by the 2-decyl derivative. |
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