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The longevity of immunoglobulin preservation in canine skin utilizing Michel's fixative |
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| Authors: | Peter J. Ihrke Anthony A. Stannard Alex A. Ardans Sharon G. Yaskulski |
| Affiliation: | 1. Department of Medicine, School of Veterinary Medicine, University of California, Davis, California, USA;2. Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA |
| Abstract: | Skin biopsy specimens from 7 dogs with immune-mediated skin diseases diagnosed by routine histology and 5 dogs with other skin diseases were placed in Michel's transport medium for 4 to 9 years. Direct immunofluorescence yielded positive results in tissue samples from 3 dogs with pemphigus foliaceus and 2 dogs with discoid lupus erythematosus. Direct immunofluorescence was not seen in tissue samples from 1 dog with pemphigus foliaceus and 5 dogs with non immune-mediated skin diseases. Direct immunofluorescence was seen in skin biopsy specimens maintained in Michel's medium for 4 to 8 years. |
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