Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233 |
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| Authors: | Bin Wu Xiaodan Wu Min Sun Minhui Li |
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| Institution: | 1.Ocean College, Zhejiang University, Hangzhou 310058, China;2.GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany; E-Mail: ;3.Center of Analysis and Measurement, Zhejiang University, Hangzhou 310058, China; E-Mail: ;4.Pharmacy Department, Baotou Medical College, Baotou 014060, China |
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| Abstract: | Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM. |
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| Keywords: | sesquiterpenes Pestalotiopsis sp abiotic stress tyrosinase inhibitory activities |
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