TGAb、TMAb与合并甲状腺结节的桥本病相关性研究

目的对合并甲状腺结节桥本病（HT）的血清学研究可有助于临床诊断,便于采用不同的治疗方案、合理的手术方式,以减少术后复发率、癌变率及过少腺体保留量可能造成甲状腺功能的严重不足.方法因甲状腺结节行甲状腺手术,术后病理诊断为HT合并甲状腺结节（甲状腺癌、结节性甲状腺肿、甲状腺腺瘤）的患者病例为A组,非HT组为B组.对每组术前血清学TGAB、TMAB检测结果进行统计学比较及分析,探讨每组数据中TGAB、TMAB检测数值对诊断单纯桥本氏甲状腺炎及桥本氏甲状腺炎合并甲状腺结节（甲状腺癌、结节性甲状腺肿、甲状腺腺瘤）有无特异性.结果 A组64例中有46例TGAB、TMAB检测数值呈阳性,阳性率为71.9%;B组318例中有37例阳性病例,阳性率为14.2%.对A、B组及A组各种疾病之间的数据进行统计学比较及分析,数据经检验为正态分布,A、B组之间差异有统计学意义（P〈0.05）,A组各种疾病间无统计学意义（P﹥0.05）.结论本课题对研究甲状腺结节合并HT与非HT血清TGAB、TMAB水平差异有统计学意义,甲状腺结节合并HT的A组各种疾病之间无统计学意义,对甲状腺手术有导向作用.

Correlation Research on TGAb,TMAb and Hashimoto Disease Complicated with Thyroid Nodule

Objective To perform the serological researches on Hashimoto disease（HT） complicated with thyroid nodule to be useful to make sure the clinical diagnosis,make it easier to choose an appropriate therapeutic plan and more reasonable operation,decrease the recurrence rate,the carcinogenesis rate and the thyroid insufficiency resulting from the too little thyroid tissue survived after the operation.Method The patients who underwent the thyroid surgery due to the thyroid nodule were diagnosed as HT complicated with thyroid nodule（thyroidcarcinoma,nodular goiter,thyroid adenoma） with the pathological method after the operation were taken as group A,and non-HT patients as group B.The results from the TGAB,TMAB serological tests before the operation were compared and analyzed to discuss whether the TGAB,TMAB testing result was specifically related to the diagnosis of Hashimoto thyroiditis and HT complicated with thyroid nodule（thyroidcarcinoma,nodular goiter,thyroid adenoma）.Results The TGAB and TMAB testing values of 46 cases in group A were positive and the positive rate was 71.9%,and the values of 37 cases in group B were positive and the positive rate was 14.2%.The statistic analysis showed that the data were in a normal distribution and the difference between group A and B was P0.05,indicating that the difference was significant.The differences among the various diseases in group A were P0.05,there was no significance in statistics.Conclusion The TGAB and TMAB test result show that it is conducive to the study on the difference in TGAB and TMAB levels between the patients HT complicated thyroid nodule and non-HT in statistics,and instructive to the thyroid operation.