Benzathine Penicillin G and Procaine Penicillin G in Piglets: Comparison of Intramuscular and Subcutaneous Injection |
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| Authors: | Ranheim B. Ween H. Egeli A.K. Hormazabal V. Yndestad M. Søli N.E. |
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| Affiliation: | (1) Department of Pharmacology, Microbiology and Food Hygiene, Norway;(2) Department of Reproduction and Forensic Medicine, The Norwegian School of Veterinary Science, PB, 8146 Dep., NO-0033 Oslo, Norway |
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| Abstract: | The disposition of penicillin G in piglets is described after intramuscular or subcutaneous injection of depot preparations. The piglets were injected with 33 000 IU/kg or 100 000 IU/kg benzathine + procaine penicillin G intramuscularly or subcutaneously, or 100 000 IU/kg procaine penicillin G intramuscularly or subcutaneously. Intramuscular injection of benzathine + procaine penicillin resulted in higher maximum concentration in plasma (Cmax) than did subcutaneous injection. The mean residence time (MRT) of penicillin G was longer when the drugs were injected subcutaneously rather than intramuscularly. The plasma concentration versus time profiles of the subcutaneous injections of benzathine + procaine penicillin revealed secondary peaks, possibly reflecting a certain degree of inflammation at the injection site. |
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| Keywords: | antibiotics benzathine penicillin depot therapy procaine penicillin pharmacokinetics route of administration |
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