Effect of lipopolysaccharide (LPS) injection on the immune responses of LPS-sensitive mice |
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Authors: | Ogikubo Yasuaki Norimatsu Mari Sasaki Yoshimasa Yasuda Akinori Saegusa Junzo Tamura Yutaka |
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Affiliation: | National Veterinary Assay Laboratory, Tokura, Kokubunji, Tokyo, Japan. |
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Abstract: | The effect of lipopolysaccharide (LPS) on humoral and cell-mediated immunity was assessed using LPS-sensitive C3H/HeN mice. A single injection of LPS significantly decreased the anti-sheep red blood cells (SRBC) antibody titers, but not the number of anti-SRBC antibody producing spleen cells. In contrast, double LPS injection did not significantly decrease the anti-SRBC titers and even increased the number of anti-SRBC antibody producing spleen cells. Similarly, single LPS injection significantly suppressed the swelling of the footpad, but double LPS injection caused milder suppression. These results suggest that a difference in the level and timing of exposure to LPS may influence the immune response to infection or vaccination. |
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