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禽大肠杆菌病疫苗研究进展
引用本文:马兴树.禽大肠杆菌病疫苗研究进展[J].中国畜牧兽医,2015,42(1):234-244.
作者姓名:马兴树
作者单位:河北工程大学农学院分子生物学实验室, 邯郸 056021
基金项目:河北省教育厅科技支撑计划项目(13226602D)
摘    要:禽致病性大肠杆菌(APEC)是引起家禽多种肠外疾病如气囊炎、心包炎、肝周炎、蜂窝织炎及败血症的主要人畜共患病原菌.在过去的数十年间,试验了多种不同类型的疫苗用于本病的控制.鉴于APEC血清型较多且不同血清型之间缺乏交叉免疫保护,故生产上使用的APEC疫苗研究进展缓慢.作者对不同类型APEC疫苗进行了综述并提出未来的研究方向.

关 键 词:禽大肠杆菌病  灭活疫苗  弱毒疫苗  亚单位疫苗  广谱疫苗  未来疫苗  
收稿时间:2014-09-16

Research Progress on Vaccines of Avian Colibacillosis
MA Xing-shu.Research Progress on Vaccines of Avian Colibacillosis[J].China Animal Husbandry & Veterinary Medicine,2015,42(1):234-244.
Authors:MA Xing-shu
Institution:Laboratory of Molecular Biology, College of Agriculture, Hebei University of Engineering, Handan 056021, China
Abstract:Avian pathogenic Escherichia coli (APEC) is one of the most important zoonotic pathogens of a number of extra-intestinal diseases in the poultry industry, including airsacculitis, pericarditis, perihepatitis, cellulitis and septicemia. Various types of vaccine have been tested over the past few decades for control of avian colibacillosis. Unfortunately, vaccines used in poultry production make the slow progress of the researches, to date, as APECs are serotypically diverse with vaccines failing to cross-protection against heterologous challenge. Herein, we review the different categories of APEC vaccines that have been tested and provide an insight into the future of APEC vaccines.
Keywords:avian colibacillosis  inactivated vaccine  attenuated vaccine  subunit vaccine  broad-spectrum vaccine  future vaccine
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