红葡萄酒大鼠在体内的抗氧化作用研究

将36只大鼠分为红葡萄酒组、食用酒精组、水组,每组又分为5ml/kg、10ml/kg、15ml/kg体重3个小组进行灌胃,灌胃12w后,测量肝脏SOD、GSH-PX、CAT酶活性及MDA含量的变化。结果表明:红葡萄酒对大鼠体重的增长与对照相比没有影响。红葡萄酒10ml/kg体重灌胃组大鼠SOD酶活性显著高,CAT活性各剂量组均提高。GSH-PX活性三个剂量组均显著提高,而酒精组大鼠只5ml／kg、10ml／kg两个剂量组有极显著提高。红葡萄酒组大鼠肝脏MDA含量明显减少,其中10ml／kg剂量组与对照相比,具有显著性差异。认为适量饮用红葡萄可提高抗氧化酶的活性,有助于身体健康。

Influence of Red Wine on Liver Antioxidation in Rats

36 male Sprague-Dawlery rats were put in 9 groups: wine (3 groups), alcohol (3 groups) and water (3 groups). Wine (12.5% v/v), alcohol (12.5% v/v) or water were given orally every day at the following doses 5ml/kg, 10ml/kg, 15 ml/kg. After 12 weeks, the livers were analysed for superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT) enzyme and maleic dialdehyde (MDA). Changes in liver morphology and physiology were observed. Results showed that the weight of rats fed with red wine did not increase compared with control; the activity of SOD enzyme increased significantly only in the red wine 10 ml/kg group; the activity of CAT enzyme in all rats increased, and so did GSH-PX. MDA content decreased significantly in the red wine 10ml/kg group compared with that of control. Red wine may improve the activity of superoxide dismutase, glutathione peroxidase , catalase enzyme,and it is useful to body health.