Alzheimer's disease: current status of etiopathogenesis and therapeutic strategies

Alzheimer's Disease (AD) is one of the most common age-related neurodegenerative diseases. It is the most prevalent form of dementia, a general term for memory loss. It is characterized by progressive cognitive dysfunction, various behavioral and neuro-psychiatric disturbances that seriously interfere with daily life. Scientists have identified factors that appear to play a role in the development of AD but no definitive causes have been found for this complex disorder. The pathogenesis of Alzheimer's disease is highly complex. While several pathologies characterize this disease, amyloid plaques and neurofibrillary tangles are hallmark neuropathological lesions in AD brain. Current AD therapies are merely palliative and only temporarily slow cognitive decline and treatments that address the underlying pathologic mechanisms of AD are still lacking. In this review, we focus on the current aspects of AD ranging from the key risk factors for AD, the underlying pathogenic events and the novel medications including disease-modifying properties.