CNS pharmacological effects of the total alkaloidal fraction from Albizia inopinata leaves |
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| Authors: | Assis T S Almeida R N Barbosa-Filho J M Medeiros I A |
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| Affiliation: | Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraı́ba, Caixa Postal 5009, CEP: 58051-970, João Pessoa, Paraı́ba, Brazil |
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| Abstract: | The total alkaloidal fraction of Albizia inopinata leaves (FLA) was investigated for its central nervous system (CNS) effects. FLA (10 mg/kg, i.p.) significantly reduced (45%) the locomotor activity in mice. In addition, it inhibited the conditioned avoidance response behavior and induced ptosis in rats. On the other hand, FLA did not exert significant effect on catalepsy, but potentiated the haloperidol-induced catalepsy. No effect was observed on sleep induced by sodium pentobarbital or apomorphine-induced stereotypes. |
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