Spatial coordination of spindle assembly by chromosome-mediated signaling gradients |
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Authors: | Caudron Maïwen Bunt Gertrude Bastiaens Philippe Karsenti Eric |
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Institution: | Cell Biology and Biophysics Department, European Molecular Biology Laboratory (EMBL), EMBL, 69117 Heidelberg, Germany. |
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Abstract: | During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle. |
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