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Lymphoma with cutaneous involvement in three domestic rabbits (Oryctolagus cuniculus)
Authors:Stephen D White  Terry Campbell  Ava Logan  Anna Meredith  Patricia Schultheiss  Tom Van Winkle  Peter F Moore  Diane K Naydan  & Francine Mallon
Institution:Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, College of Veterinary Medicine, Fort Collins, Colorado 80523, USA,;University Laboratory Resources Section, The School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, Pennsylvania 19104–6008, USA,;Exotic and Laboratory Animal Services, Royal (Dick) School of Veterinary Studies, Department of Veterinary Clinical Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK,;Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, College of Veterinary Medicine, Fort Collins, Colorado 80523, USA,;Department of Pathobiology, The School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, Pennsylvania 19104–6008, USA,;Department of Pathology, School of Veterinary Medicine, University of California, Davis, California 95616, USA,;Veterinary Teaching Hospital, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Abstract:Three domestic rabbits ( Oryctolagus cuniculus ) with cutaneous lymphoma are described. Two rabbits were young (7 weeks and 1 years) and were euthanized within 1 week of showing clinical signs. Lymphoma was found in the skin and internal organs. The third rabbit was 9.5 years of age, and lived for more than 1 year after diagnosis. No response was seen to either 2 months of alpha-interferon administration or a 2.5-week course of isotretinoin treatment. After 1 year the rabbit died suddenly; the owner refused necropsy. Immunologic stains of the tumour in all three rabbits showed T cells to be the lymphoma cell type.
Keywords:alpha-interferon  cutaneous lymphoma  lymphoma  rabbit  retinoids  skin
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