Evaluation of a long‐acting injectable formulation of omeprazole in healthy dogs |
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| Authors: | Adesola Odunayo Gina Galyon Joshua Price Silke Hecht M. Katherine Tolbert |
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| Affiliation: | 1. Department of Small Animal Clinical Sciences, University of Florida, Gainesville Florida, USA ; 2. Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville Tennessee, USA ; 3. Office of Information and Technology, University of Tennessee, Knoxville Tennessee, USA ; 4. Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station Texas, USA |
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| Abstract: | BackgroundTo evaluate the efficacy of a single intramuscular adminsitration of long‐acting omeprazole (LA‐OMEP) in increasing gastric pH in dogs.HypothesisWe hypothesized that LA‐OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration.AnimalsNine healthy research dogs.MethodsProspective experimental study. Dogs were given a 4 mg/kg intramuscular injection of LA‐OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were determined.ResultsThe mean onset of action for the LA‐OMEP was 98.11 min (SD 46.39). The mean number of days the dogs'' pH met established goals for MPT pH ≥3 was 5.5 days (range, 3‐7) and 5.25 days for MPT pH ≥4 (range, 3‐7). Long‐acting omeprazole met the human clinical goals pH ≥3 for 72 hours in 8/8 of the dogs and MPT pH ≥4 for 96 hours in 7/8 of dogs.Conclusions and Clinical ImportanceThe LA‐OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5 days and up to 7 days, after a single intramuscular injection. No major adverse effects were observed. |
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| Keywords: | acid suppression bravo monitoring canine intragastric pH proton pump inhibitor |
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