Frameless stereotactic radiotherapy alone and combined with temozolomide for presumed canine gliomas |
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Authors: | M Dolera L Malfassi C Bianchi N Carrara S Finesso S Marcarini G Mazza S Pavesi M Sala G Urso |
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Institution: | 1. La Cittadina Fondazione Studi e Ricerche Veterinarie, Romanengo, Italy;2. Azienda Socio Sanitaria Territoriale di Lodi, Lodi, Italy |
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Abstract: | We evaluated stereotactic volume modulated arc radiotherapy (VMAT) for canine gliomas, alone (radiotherapy RT]) and in combination with temozolomide (RT + TMZ), compared with palliation. Overall and disease‐specific survival times were estimated. Thirty dogs were palliated, 22 dogs were treated with RT and 20 with RT + TMZ. Complete and partial responses were observed in 63.2% and 90.9% of patients in the RT and RT + TMZ arms, respectively, that were alive at 1 year. Median survival in the palliation arm was 94 days (95% conformity index CI] 87÷101). Median survivals of the RT arm (383 days, 95% CI 276÷490) and RT+TMZ arm (420 days, 95% CI 280÷560) were not significantly different (P = .61). Positive correlation with survival was found both for the ratio between target and brain (relative) volume of the tumour of <5% (P = .013) and for a clinical presentation with normal mentation (P = .032). VMAT is feasible and effective for canine brain gliomas. Combining this therapy with TMZ did not elicit any additional improvement in survival time. |
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Keywords: | dog glioma radiotherapy stereotaxis temozolomide |
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