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Oxygen affinity in red cells: changes induced in vivo by propranolol |
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| Authors: | F A Oski L D Miller M Delivoria-Papadopoulos J H Manchester J C Shelburn |
| Abstract: | Propranolol, a blocking agent for the beta adrenergic receptor, produces a redistribution of 2,3-diphosphoglycerate in the red cell. At concentrations of 3.3 x10(-5)M, 2,3-diphosphoglycerate in the red cell membrane becomes unbound in vitro. The administration of propranolol to hunmns produces similar changes and results in a decrease in the affinity of hemoglobin for oxygen. |
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