清燥合剂联合硝酸甘油软膏治疗血热肠燥型肛裂的疗效观察

目的 观察清燥合剂联合硝酸甘油软膏治疗血热肠燥型肛裂的临床疗效。方法 选取72例肛裂、中医辨证分型为血热肠燥型的患者，随机分为对照组和观察组，每组36例。对照组予硝酸甘油软膏局部外涂，观察组在对照组基础上予清燥合剂口服，两组均治疗7 d，比较两组疼痛评分、便秘程度评分、便血程度评分、裂口愈合时间。结果 观察组总有效率为80.56%，对照组总有效率为58.33%，两组有效率差异有统计学意义（P<0.05）；观察组疼痛评分、便秘程度评分、便血程度评分等方面效果均优于对照组（P<0.05），观察组裂口愈合时间较对照组缩短（P<0.05）。结论 清燥合剂联合硝酸甘油软膏治疗血热肠燥型肛裂，能够显著缓解疼痛，改善便秘、便血症状，促进裂口愈合，值得临床推广。

Clinical Efficacy Observation on Qingzao Mixture Combined with Nitroglycerin Ointment in the Treatment of Anal Fissure with Syndrome of Intestine Dryness Due to Blood Heat

Objective To observe the clinical efficacy of Qingzao Mixture combined with nitroglycerin ointment in the treatment of anal fissure with syndrome of intestine dryness due to blood heat. Methods A total of 72 patients with anal fissure who had syndrome of intestine dryness due to blood heat were equally and randomly divided into control group and observation group. The control group was given external application of nitroglycerin ointment, while the observation group was orally given Qingzao Mixture in addition to the treatment for the control group. The course of treatment was 7 days for both groups. The pain score, constipation score, blood stool score, and fissure healing time were compared between the two groups. Results There was a significant difference in overall response rate between the observation group and the control group (80.56% vs 58.33%, P<0.05). Compared with the control group, the observation group had significantly more improvements in pain score, constipation score, and blood stool score (P<0.05) and had a significantly shorter fissure healing time (P<0.05). Conclusion Qingzao Mixture combined with nitroglycerin ointment can significantly relieve pain, improve constipation and blood stool symptoms, and promote fissure healing in the treatment of anal fissure. It holds promise for clinical application.